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Sample Size for declaring freedom from disease in a clustered population

This model estimates the sample size needed to substantiate declaring that a population has freedom from a given disease. This model explicitly accounts for clustering within the population.

Geographical Scale

  • Biological cluster of interest

Required Data

  • None

Suggested Data

  • None

User Inputs

  • Total population size estimate
  • Average cluster size
  • Correlation of disease status within cluster
  • Diagnostic test sensitivity.

Outputs

  • The number of animals that need to be tested to have high probability (95%) that disease prevalence in the overall population is at or below 1% or 2%.

graph of sample size vs probability of freedom from disease at a given prevaence

Example of model output showing sample size required to substantiate disease prevalence below 1% and 2% prevalence.

More information